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Long noncoding RNA in liver diseases Kenji Takahashi, Irene Yan, Hiroaki Haga and Tushar Patel* Article first published online: 20 JUN 2014 DOI: 10.1002/hep.27043 © 2014 by the American Association for the Study of Liver Diseases Issue Hepatology Hepatology Volume 60, Issue 2, pages 744–753, August 2014 Article has an altmetric score of 2 Additional Information(Show All) How to CiteAuthor InformationPublication History Potential conflict of interest: Nothing to report. Supported in part by grants DK069370 and TR000884 from the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. SEARCH Search Scope Search String Advanced > Saved Searches > ARTICLE TOOLS Get PDF (864K) Save to My Profile E-mail Link to this Article Export Citation for this Article Get Citation Alerts Request Permissions More Sharing ServicesShare|Share on citeulikeShare on facebookShare on deliciousShare on www.mendeley.comShare on twitter Abstract Article References Cited By View Full Article (HTML) Enhanced Article (HTML) Get PDF (864K) The identification of the presence of large RNA transcripts that do not code for proteins but that may have biological functions has provided an important new perspective in gene regulation. These long noncoding RNAs (lncRNAs) are being increasingly recognized to contribute to many biological processes through diverse mechanisms. The roles of these emerging genes are being recognized across kingdoms. These findings are profoundly altering our understanding of disease pathobiology and leading to the emergence of new biological concepts underlying human diseases. Strategies for the discovery and characterization of lncRNAs are highlighted. Several lncRNAs have been described in liver disease, and in liver cancers in particular. Their molecular mechanisms of action, function, and contributions to disease pathophysiology are reviewed. LncRNA genes associated with liver diseases have potential roles as biomarkers of disease diagnosis, prognosis, or therapeutic response as well as direct targets for therapeutic intervention. Conclusion: The emerging knowledge in this rapidly advancing field offers promise for new fundamental knowledge and clinical applications that will be relevant for human liver diseases. (Hepatology 2014;60:744–753)
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